Endocrine Abstracts

Introduction: Generously supported by IPSEN)-->Clinically nonfunctioning pituitary adenomas (CNFPA) represent 25–50% of all pituitary lesions. They may be asymptomatic and discovered incidentally or they may be diagnosed due to visual impairment or symptoms of pituitary hormone insufficiency. There is little data on apoplexy frequency in the CNFPA.The aim of our study was to assess the frequency of CNFPA a...

Introduction: The association of thyroid disorders including autoimmune thyroiditis with the risk for breast cancer is controversial (1–4). A recent study found that triidothyronine (T3) levels are positively associated with breast cancer specific mortality (5). Experimental studies have shown that T3 mimics the effects of estrogen in human breast cell lines and induces the expression of progesterone receptors (6).Purpose: The ...

Reactive oxygen species (ROS) are involved in the pathogenesis of atherosclerosis. Atrial natriuretic peptide (ANP) reduces thioredoxin in heart failure patients, whereas adrenomedullin, acting as an antioxidant, protects rat cardiomyocytes from infarction and mouse vascular smooth muscle cells from angiotensin II (AII) oxidative effect. Besides AII, aldosterone (Aldo) is also an activator of ROS. Aim of the study was the investigation of the eventual antioxidant effect of ANP...

Introduction: Treatment options for progressive metastatic unresectable medullary thyroid carcinoma (MTC) include tyrosine kinase inhibitors (TKIs) or somatostatin analogues (SSA), although the efficacy of the latter is debatable. In such cases, combined treatment of TKIs and SSAs has not previously been reported.Aim: To present a metastatic MTC case successfully treated with a combination of Vandetanib and Lanreotide Autogel.Case ...

Introduction: Only few studies were observed, supporting the hypothesis that the administration of high doses of vitamin E in people with elevated serum total cholesterol levels leads to increased adrenocortical hormone secretion. There are only limited data concerning androgen or estrogen levels. The aim of this study is to investigate the possible effect of Vitamin E on adrenal and sex hormones in rabbits with hypercholesterolemia, as an animal model for the research.<p ...

Background: Although papillary thyroid carcinoma (PTC) is considered to have an excellent prognosis, some more aggressive variants have been identified that show reduced overall survival rates. Besides from the diffuse sclerosing, tall cell, columnar cell, and solid variant, the hobnail variant was newly recognized as one of these aggressive forms, affecting recurrence, metastasis, and overall survival rates.Methods: We performed a systematic review and ...

Objective: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk.<p class="...

Introduction: Women with non-metastatic breast cancer form a distinct subpopulation in which calcium homeostasis in response to treatment with denosumab has not been extensively investigated.Methods: Female patients with osteoporosis, who were eligible for treatment with denosumab, were prospectively enrolled (2011–2012) and divided into two groups; Group A consisting of patients with either no history or benign diseases non affecting bone metabolis...

Introduction: Armadillo-containing repeat protein 5 gene (ARMC5) is a tumor suppressor gene expressed in different human tissues. Inactivating germline and somatic mutations of the gene are involved in the pathogenesis of primary bilateral macronodular adrenocortical hyperplasia (PBMAH). These mutations are mainly met in the familial form of PBMAH and are associated with a more severe Cushing Syndrome, meningiomas and T-cell immune response defects. However, the role of ARMC5 ...

Objective: Clinically apparent hypocalcaemia following total thyroidectomy occurs in 20–25% of patients subjected to total thyroidectomy, in 2-4% of these patients the hypocalcaemia is permanent. Treatment by per-os or iv administration of calcium supplements and vitamin D is suggested when the serum calcium concentration falls bellow a critical level, either before or whenever the patients develop clinical symptoms of tetany. The purpose of this study is to evaluate the ...